姓名:冯景
职称/职务:主任技师/副院长
工作单位:香港中文大学(深圳)附属第二医院
电子邮箱:fengjing71921@163.com
研究领域:临床检验/科研管理
基本资料(出生年月、学习和工作经历、教科研成果总体情况、学术兼职等)
冯景,男,主任技师,博士生导师,现为香港中文大学(深圳)附属第二医院副院长。是上海市卫生系统优秀学科带头人,上海市医学领军人才,上海市重点专科带头人。主要从事临床检验与分子诊断及科研管理。研究方向主要聚焦:1.三阴性乳腺癌发生机制与新靶点筛选;2.肿瘤诊断与治疗新技术。培养硕士、博士、博士后35名,主持包括国家自然科学基金项目在内各级课题8项。
主持在研课题:
1.L3MBTL3稳定c-myc促进乳腺癌发生发展的功能与机制研究,国家自然科学基金面上项目,82173044,54.7万元,主持,在研;
2.L3MBTL3特异性结合激活STAT3促进乳腺癌转移的机制研究,龙岗区科创局重点大项目,LGKCYLWS2022-001,50万元,主持,在研。
代表性研究成果:
1. Fang, H, Ren, W, Cui, Q, Liang, H, Yang, C, Liu, W, Wang,X, Liu, X, Shi, Y,Feng, J*,Chen, C*.Integrin β4promotes DNA damage-related drug resistance in triple-negative breast cancervia TNFAIP2/IQGAP1/RAC1.Elife,2023, Oct 3;12:RP88483.
2.Xu, L, Deng, H, Wu, L, Wang, D, Shi, L, Qian, Q, Huang, X, Zhu, L, Gao, X,Yang, J, Su, Y,Feng, J*,Zhu, X*.Supramolecular Cyclic Dinucleotide Nanoparticles for STING-Mediated CancerImmunotherapy.ACS Nano,2023, May 30;17(11): 10090-10103.
3.MengmengHan # , Jialun Li # , Yaqiang Cao # , Yuanyong Huang, Wen Li, Haijun Zhu,QianZhao, Jing-Dong Jackie Han, Qihan Wu, Jiwen Li,Jing Feng*,and JieminWong*.A role for LSH in facilitating DNA methylation by DNMT1 throughenhancing UHRF1 chromatin association[J].Nucleic Acids Res.2020 Dec 2;48(21):12116-12134.
4.YingLiu # , Fei Xie # , Jialun Li, Jianpeng Xiao, Jie Wang, Zhaolin Mei, HongjiaFan, Huan Fang, Sha Li, Qiuju Wu, Lin Yuan, Cuicui Liu, You Peng, Weiwei Zhao,Lulu Wang, Jiemin Wong,Jing Li*, Jing Feng*.SETDB2 promotedbreast cancer stem cell maintenance by interaction with and stabilization of ΔNp63 α protein.Int. J. Biol. Sci.2020; 16(12): 2180-2191.
5.ShaLi # , Yijing Wu, Fei Ding, Jiapei Yang, Jing Li,Xihui Gao * , Chuan Zhang* , and Jing Feng*. Engineering macrophage-derived exosomes for targetedchemotherapy of triple-negative breast cancer.Nanoscale,2020 May 21;12(19):10854-10862.