导师简介——刘文婷

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       

姓名： 刘文婷

职称/职务：副教授

工作单位： 湖北医药学院公共卫生与健康学院

电子邮箱：liuwentingnz@outlook.com            

研究领域：生物信息学；智能医学；复杂疾病的发病机制、生物标志物及基因调控通路，靶向药物反应机制等。

基本资料（出生年月、学习和工作经历、教科研成果总体情况、学术兼职等）：

刘文婷，1984年10月出生，博士，2015年毕业于新加坡南洋理工大学生物医学信息学研究中心，于新加坡基因组研究院和美国加州大学洛杉矶分校系统生物学系完成博士后训练。曾任教于新西兰林肯大学。现任湖北医药学院硕士生导师，副教授，智能医学工程专业负责人。入选湖北省“百人计划”。主要研究方向是运用人工智能及网络深度学习融合多组学数据研究复杂疾病的致病机制。主持省自然科学基金一项。已发表科研论文20篇，包括SCI论文16篇，计算机国际会议论文4篇，其中9篇以第一作者或通讯作者的身份发表。

代表性研究成果：

1.       教科研项目

主持湖北省自然科学基金项目《基于生物网络的多组学融合系统探索食管癌的发病机制》，10万元，2021.10.1-2023.9.30。

主持湖北医药学院人才启动科研项目《基于生物网络的多组学数据系统性融合模型在生物标志物发现中的应用研究》，10万元，2021.1.1-2024.12.31。

2.       期刊论文

发表的SCI论文有：

[1]   S.G. Jung*, Wenting Liu*, J.W. Baek, J.W. Moon,B.D. Ye, H.S. Lee, S.H. Park, S.K. Yang, J.J. Liu, K. Song. ExpressionQuantitative Trait Loci (eQTL) Mapping in Korean Patients With Crohn's Diseaseand Identification of Potential Causal Genes Through Integration With Disease Associations.Frontiers in Genetics. 2020 May 14;11:486. doi: 10.3389/fgene.2020.00486.eCollection 2020.(impactfactor: 3.789)PMID: 32477412 PMCID: PMC7240107

[2]   Wenting Liu, Sharmila Venugopal, Sana Majid, InSook Ahn, Graciel Diamente, Jason Hong, Xia Yang and Scott H. Chandler.Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice revealsperturbed cell types and pathways of amyotrophic lateral sclerosis.Neurobiology of Disease. 2020. Apr 30;141:104877.(impact factor: 5.332) PMID: 32360664

[3]   Lunfei Liu*, Wenting Liu*, Yuxin Zheng, Jisu Chen,Jiong Zhou, Huatuo Dai, Suiqing Cai, Jianjun Liu, Min Zheng, Yunqing Ren. Anti-TNF-α Treatment-relatedPathways and Biomarkers Revealed by Transcriptome Analysis in Chinese PsoriasisPatients.BMCSystems Biology.2019 Apr 5;13(Suppl 2):29. (impact factor: 2.505)PMID:30953507

[4]   WentingLiuand Jagath C. Rajapakse. Fusing Gene Expression and TransitiveProtein-Protein Interaction for Gene Regulatory Networks. BMCSystems Biology. 2019 Apr 5;13(Suppl 2):37. (impact factor: 2.505)PMID:30953534

[5]   WentingLiu,Jianjun Liu, and Jagath C. Rajapakse. Gene OntologyEnrichment Improves Performances of Functional Similarity of Genes. ScientificReports. 2018, 8:12100. (impact factor: 4.609) PMID: 30108262 PMCID:PMC6092333        

[6]   WentingLiu,Guangxia Li, James Cheng: Fast PageRank Approximation by AdaptiveSampling. Knowledge and Information Systems,2013, pp.1-20. (impact factor: 2.247)

[7]   WentingLiu,Kui Miao, Guangxia Li, Kuiyu Chang, Jie Zheng and Jagath C. Rajapakse: ExtractingRate Changes in Transcriptional Regulation from MEDLINE Abstracts. BMCBioinformatics, 2014, 15 (Suppl 2): S4. (impact factor: 3.114) PMID:24564647 PMCID: PMC4015878        

[8]   Woo Chin Cheng, Wenting Liu, Lin Xiao Yun, Rajkumar Dorajoo, A Mark Richards, LeeChuen Neng, Thidathip Wongsurawat, Intawat Nookaew, Vitaly Sorokin. The miRNA30b-5p - mRNA MBNL1 interaction is involved in human VSMC differentiation inhuman with coronary atherosclerosis. International Journal of MolecularSciences. 2019 Dec 18;21(1):11. (impact factor: 4.183) PMID: 31861407 PMCID: PMC6982107        

[9]   Yunqing Ren, Wenting Liu,Jisu Chen, Jianyou Wang, Ke Wang, Jiong Zhou, Sui-Qing Cai, Min Zheng, JianjunLiu, Lunfei Liu, and Dan Xue. The missense mutation of the ABCC11 gene isassociated with Axillary Osmidrosis susceptibility and clinical phenotypes inChinese Han Population. Scientific Reports. 2017, 7:46335.(impact factor: 4.609) PMID: 28485377 PMCID:PMC5423033

[10]Hong Li*, Qiang Li*, Yixuan Zhang, Wenting Liu, Bo Gu, Taro Narumi, KinLung Siu, Ji YounYoun, Peiqing Liu, Xia Yang, Hua Cai. Novel Treatment ofHypertension by Specifically Targeting E2F for Restoration of EndothelialDihydrofolate Reductase and eNOS Function Under Oxidative.  Hypertension. 2019Jan;73(1):179-189. (impact factor: 6.739)PMID:30571557 PMCID: PMC6310047

[11]Angela NBarrett, Chui-Yee Fong, Arjunan Subramanian, Wenting Liu, Yirui Feng, Mahesh Choolani, Arijit Biswas, Jagath CRajapakse, Ariff Bongso.Human Wharton’s Jelly Mesenchymal Stem Cells Show Unique Gene ExpressionCompared to Bone Marrow Mesenchymal Stem Cells Using Single-Cell RNA-Sequencing. Stem Cells and Development.2019 Feb 1;28(3):196-211. (impactfactor: 3.651)PMID: 30484393

[12]Hong Liu*, Zhen-zhen Wang*,YiLi*,Gong-qi Yu, Xi-an Fu,Chuan Wang, Wen-Ting Liu, Yong-xiang Yu, et al.Genome-wideAnalysis of Protein-Coding Variants in Leprosy. Journal ofInvestigative Dermatology, 2017, 137(12):2544-2551. (impact factor:6.880) PMID: 28842327

[13]Rajkumar Dorajoo, Rick Twee-Hee Ong,Xueling Sim, Ling Wang, Wenting Liu, E Shyong Tai, Jianjun Liu,Seang-Mei Saw. The contribution of recently identified adultBMI risk loci to pediatric obesity in a Singaporean Chinese childhood dataset.PediatricObesity. 2016. (impact factor: 4.361) PMID:27780307

[14]Hong M, Ye BD, Yang SK, Jung S, LeeHS, Kim BM, Lee SB, Hong J, Baek J, Park SH, Han B, Li Y, Liu W, Haritunians T, Taylor KD, Rotter JI, Bang SY, Kim TH,McGovern DPB, Liu J, Song K.Immunochip Meta-Analysis of Inflammatory BowelDisease Identifies Three Novel Loci and Four Novel Associations in PreviouslyReported Loci.J Crohns Colitis. 2018 May25;12(6):730-741. (impact factor:6.992)PMID:29584801

[15]Yonova-Doing E, Zhao W, Igo RP Jr,Wang C, Sundaresan P, Lee KE, Jun GR, Alves AC, Chai X, Chan ASY, Lee MC, FongA, Tan AG, Khor CC, Chew EY, Hysi PG, Fan Q, Chua J, Chung J, Liao J, ColijnJM, Burdon KP, Fritsche LG, Swift MK, Hilmy MH, Chee ML, Tedja M, BonnemaijerPWM, Gupta P, Tan QS, Li Z, Vithana EN, Ravindran RD, Chee SP, Shi Y, Liu W, Su X, Sim X, Shen Y, Wang YX, LiH, Tham YC, Teo YY, Aung T, Small KS, Mitchell P, Jonas JB, Wong TY, FletcherAE, Klaver CCW, Klein BEK, Wang JJ, Iyengar SK, Hammond CJ, Cheng CY. Commonvariants in SOX-2 and congenital cataract genes contribute to age-relatednuclear cataract. Commun Biol. 2020 Dec 11;3(1):755.(impact factor:4.165) PMID: 33311586; PMCID: PMC7733496.        

[16]Guangxia Li, Steven C. H. Hoi, KuiyuChang, Wenting Liu, Ramesh Jain: Collaborative OnlineMultitask Learning. IEEE Transactions on Knowledge and DataEngineering26(8): 1866-1876 (2014). (impact factor:3.692)        

计算机国际会议论文有：

[17]WentingLiu,Kuiyu Chang, Jie Zheng, Jain Divya, Jung-Jae Kim, Jagath C. Rajapakse. GeneRegulatory Networks from Gene Ontology. International Symposium on BioinformaticsResearch and Applications (ISBRA), 2013.Bioinformatics Research and Applications, Lecture Notes in Computer Science, Vol.7875, 2013, pp. 87-98.        

[18]WentingLiu,Zhang Yilei, Extracting Rate-changes in TranscriptionalRegulation by Word Embedding with Sentence Structure and Domain Knowledge inDeep Neural Networks, 18th IndustrialConference (ICDM), 2018, New York, USA, July 2018,Advances in Data Mining Proceedings: 199-205.        

[19]Zhen Hai, Gao Cong, Kuiyu Chang, Wenting Liu, Peng Cheng: Coarse-to-fine Review Selection via SupervisedJoint Aspect and Sentiment Model.ACMSpecial Interest Group on Information Retrieval (SIGIR) 2014:617-626.        

[20]Guangxia Li, Kuiyu Chang, StevenC. H. Hoi, Wenting Liu, Ramesh Jain:CollaborativeOnline Learning of User Generated Content. ACMInternational Conference on Information and Knowledge Management (CIKM) 2011:285-290.        

3.       出版的学术专著和教材

《Python医学数据分析实战》赵军、刘文婷编著。2021年。人民邮电出版社出版。

4.       其他